Laser Research & Publications

  • MSK
  • Joints
  • NEURO
  • WOUND
  • BRAIN
  • ONCOLOGY
  •  How PBM works?
  • BLUE Laser
  • Fractional Laser
  • EQUINE

Effect of Low Level Laser Application at the End of Surgery to Reduce Pain after Tonsillectomy in Adults

1) Department of Anesthesia, Tabriz University of Medical Sciences, Tabriz, Iran

2) Department of Otorhinolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran

3) Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: clinical and histological findings after excisional biopsy of benign oral lesions

“Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: clinical and histological findings after excisional biopsy of benign oral lesions”

Acneiform rash due to epidermal growth factor receptor inhibitors: high-level laser therapy as an innovative approach

The high-level laser therapy was effective in the healing of acneiform rash associated with epidermal growth factor receptor inhibitors with no side effects.

Clinical effectiveness of laser acupuncture in the treatment of temporomandibular joint disorder

a) School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan

b) Department of Dentistry, Oral Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan

c) Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

1) Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy

2) Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy

3) Department of Genetics, Federal University of Pernambuco, Recife, Brazil

4) Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, Italy

5) Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, 35131 Padova, Italy

Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells

1) University of Trieste, Trieste, Italy

2) INSERM U955 Eq.16, Institut Mondor de Recherche Biomédicale and VRI (Vaccine Research Institute), Créteil, France

3) INSERM U955 Eq. 16, Institut Mondor de Recherche Biomédicale and Université Paris Est- Créteil (UPEC), Faculté de Médecine, Créteil, France

4) Institute for Maternal and Child Health “Burlo Garofolo”, Trieste, Italy

Photobiomodulation therapy reduces viral load and cell death in ZIKV-infected glioblastoma cell line

Received: 21 May 2018

Accepted: 21 June 2018

# Springer-Verlag London Ltd., part of Springer Nature 2018

MSK

High intensity laser for pain relief in footballers - muscle injuries

1)J Back Musculoskelet Rehabil 2024

2) Dalila Scaturro 1Alessandro de Sire 2 3Fabio Vitagliani 4Davide Lo Nardo 4Sofia Tomasello 5Antonio Ammendolia 2 3Giulia Letizia Mauro 1

Results: Group A athletes had a greater benefit on pain (4.65 ± 0.61 vs 3.24 ± 0.63; p< 0.05) and muscle injury recurrence. The return to play in the athletes of group A took place 4.73 days earlier.

Photobiomodulation Therapy Plus Usual Care Is Better than Usual Care Alone for Plantar Fasciitis: A randomized Controlled Trial

Ann K Ketz 1, Juanita Anders 2, Judy Orina 3, Betty Garner 4, Misty Hull 3, Nicholas Koreerat 5, Jeff Sorensen 3, Candice Turner 5, James Johnson 6

Int J Sport Phys Ther 2024 Jan 2;19(1):1438-1453. doi: 10.26603/001c.90589. eCollection 2024.

Hight Intensity laser therapy & ESW with Plantar Fasciitis

Marzieh Zare Bidoki, MD, Mohammad Reza Vafaeei Nasab, MD, and Amidodin Khatibi Aghda, MD

IIran J Med Sci. 2024



ESWT and HILT decrease pain and increase patient satisfaction in PF. Besides, both methods are non-invasive and safe. However, there is a significant difference between them, and HILT is more effective.

HILT and carpal Tunnel Syndrome

1) Am J Phys Med Rehabil 2024

2) Mohamed M ElMeligie 1Mahmoud M Ismail 2Yasmine S Gomaa 3Amr M Yehia 4Hend R Sakr 5Omnia M ElGendy 6

3) Review

Moderate evidence exists regarding efficacy of HILT compared to placebo, HILT + wrist splint, and exercise in a short period of follow-up time

HILT and Epicondylitis (tennis elbow) compare to chock wave

1) Rheumatol Int 2024 

2) Sidika Buyukvural Sen 1Meryem Kosehasanogullari 1Nurhan Okur Yilmaz 1Burhan Fatih Kocyigit 2

HILT demonstrated greater efficacy in terms of tenderness reduction, pain relief, and disability improvement. 

Effect of Low Level Laser Application at the End of Surgery to Reduce Pain after Tonsillectomy in Adults

1) Department of Anesthesia, Tabriz University of Medical Sciences, Tabriz, Iran

2) Department of Otorhinolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran

3) Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Joints

Hight Intensity laser therapy in pain management of knee osteoarthritis

a) Biomedicines. 2024 Aug; 12(8): 1679.

b) Daniela Poenaru,* Miruna Ioana SandulescuClaudia Gabriela Potcovaru, and Delia Cinteza

c) Metareview

This paper aimed to stress the advantages of HILT based on a greater wavelength, higher energy delivery, and deeper tissue penetration. Research on 23 published trials revealed that the analgesic effect is rapid, cumulative, and long lasting. Compared to sham, to LLLT, or to other combinations of therapeutical modalities, HILT provided significantly better results on pain reduction and functional improvement. 

Comparison high intensity and low level laser therapy with exercise on pain and function of knee osteoarthritis

a)  J Lasers Med Sci 2024 

b) Majid Khalilizad 1 2Danial Hosseinzade 2Mobin Marzban Abbas Abadi 3

c) Metareview

Conclusion: Based on our findings, both HILT+ET and LLLT+ET treatments effectively reduced pain and improved function, but HILT+ET showed a more significant improvement in both outcomes compared to LLLT+ET.

Shoulder Pain in stroke patients

a)  Top Stroke Rehabil 2024 

b) Piyapat Dajpratham 1Rinlada Pongratanakul 1Tipchutha Satidwongpibool 1Nawapat Kluabwang 1Piyapong Akkathep 1Thaniyaporn Claikhem 1

After the two-week intervention, significant improvements were observed in pain reduction at rest and during motion in the HILT group,

Frozen shoulder and HILT

a)  Lasers Med Sci  2023 

b)Hernán Andrés de la Barra Ortiz 1 2Nivaldo Parizotto 3Mariana Arias 3Richard Liebano 3 

HILT into a physical therapy plan reduce pain and disability,

Neck pain and High Intensity Laser Therapy

a)  Lasers Med Sci2024

b) Hernán Andrés de la Barra Ortiz 1 2Mariana Arias 3Richard Eloin Liebano 3 4

c) metarieview

 HILT demonstrates effectiveness in reducing neck pain and disability while enhancing cervical extension when added to other physical therapy interventions, especially therapeutic exercise, based on a moderate level of evidence. This review highlights that the most favorable results are obtained when HILT is employed to address myofascial pain, cervical radiculopathy and chronic neck pain.

Neck pain and effectiveness of High Intensity Laser Therapy

a)  Physiotherapy2023

b) Yu-Hua Xie 1Man-Xia Liao 2Freddy M H Lam 3Yue-Ming Gu 4W C Hewith A Fernando 5Lin-Rong Liao 6Marco Y C Pang 7

c) metarieview

There was moderate quality evidence that HILT may improve pain intensity and cervical ROM in individuals with neck pain,

Clinical effectiveness of laser acupuncture in the treatment of temporomandibular joint disorder

a) School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan

b) Department of Dentistry, Oral Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan

c) Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

Effect of Low Level Laser Application at the End of Surgery to Reduce Pain after Tonsillectomy in Adults

1) Department of Anesthesia, Tabriz University of Medical Sciences, Tabriz, Iran

2) Department of Otorhinolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran

3) Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

NEURO

Trigeminal Neuralgia

Metareview confirming the analgesic effect of laser therapy to treat trigeminal neuralgia.

In this article you will find a list of studies of Tigeminal Neuralgia to compare wavelengths, frequency and other laser parameters

WOUND

Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells



Blue Laser on wound healing

2023 - Full article

Growth factor - Nitriic oxide - Platelet rich plasma - Stem cells

Mechanism and dosage

Photobiomodulation wound healing

2020 - Full article

Case repoort Chronis wound healing with 980nm IR

Dosage 3.18j/cm2

Mechanis action of red and IR lasers on wound healing

- 1988 - Abstract - J Orthop Sports Phys Ther

Accelerates inflammatory phase/protaglandins

Increase ATP synthesis.

Faster collagen synthesis, fibroplasia

Immunoregulation

BRAIN

Photobiomodulation on Brain cells

Full article - 2024

Increase blood flow - Decrease oxydative stress - Promote angiogenesis - Inhibit neuronal inflammation - Inhibit apoptosis - Promote neurotrophic secretion - Increase neuron progenitor cells- Increase synaptogenesis

ONCOLOGY

The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham-controlled clinical trial

a) Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women’s Health, University of Minnesota, Minneapolis, MN, Unite d States

b) Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medical School, New York, NY

Same strategy for pitfalls of radiotherapy in different anatomical districts

Received: 7 June 2011

Accepted: 3 November 2011

Published online: 26 November 2011 # Springer-Verlag London Ltd 2011

Class IV laser therapy as treatment for chemotherapy-induced oral mucositis in onco-haematological paediatric patients: a prospective study

1) Division of Oral Medicine and Pathology, Department of Dental Science, University of Trieste, Trieste, Italy

2) Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy

3) Division of Oral Medicine & Dentistry, Brigham and Women’s Hospital, Boston, MA, USA

4) International Center for Genetic Engineering and biotechnology (ICGEB), Trieste, Italy

Effect of Low Level Laser Application at the End of Surgery to Reduce Pain after Tonsillectomy in Adults

1) Department of Anesthesia, Tabriz University of Medical Sciences, Tabriz, Iran

2) Department of Otorhinolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran

3) Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Evaluation of nutritional status in head and neck radio-treated patients affected by oral mucositis: efficacy of class IV laser therapy

To retrospectively evaluate the role of class IV laser therapy in the amelioration of nutritional status of patients affected by oral mucositis due to radiotherapy of the head and neck region during oncological treatment.

Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT

To demonstrate the efficacy of laser photobiomodulation (PBM) compared to that of placebo on severe oral mucositis (OM) in pediatric oncology patients. The primary objective was the reduction of OM grade (World Health Organization [WHO] scale) 7 days after starting PBM. Secondary objectives were reduction of pain, analgesic consumption, and incidence of side effects.

Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

a) Division of Oral Medicine and Pathology, University Hospital of Trieste, Piazza dell’Ospitale 1, 34129 Trieste, Italy

b) Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99,3 4149 Trieste, Italy

c) Department of Medical, Surgical and Health Sciences, University Hospital of Trieste, Strada di Fiume 447, 34149 Trieste, Italy

d) Cellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy

e) Molecular Medicine, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy

Can laser therapy be the answer for radiodermatitis in anal cancer patients? Two case reports

The present report introduces an innovative technique based on the use of laser light to manage radiodermatitis of the anal region in a decisive fashion.

Laser surgical treatment of chronic graft-versus-host disease (cGvHD)-induced buccal mucosal sclerosis

Laser-chirurgische Behandlung der cGvHD-induzierten Sklerose der Mundschleimhaut

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

Katia Rupel, 1 Luisa Zupin, 1 Andrea Colliva, 2 Anselmo Kamada, 3 Augusto Poropat, 1 Giulia Ottaviani, 1 Margherita Gobbo, 1 Lidia Fanfoni, 1 Rossella Gratton, 4 Massimo Santoro, 5 Roberto Di Lenarda, 1 Matteo Biasotto, 1 and Serena Zacchignacorresponding author 1 , 2

Oxyid Med Cell Longev, 2018; 2018: 6510159

Preliminary study in a new protocol for the treatment of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and chemotherapy (CT)

Received: 5 May 2016

Accepted: 15 June 2017 # Springer-Verlag London Ltd. 2017

Antiviral properties of blue laser in an in vitro model of HSV-1 infection

 How PBM works?

Mechanisms of photobiomodulation (Red/IR)- Dive into complexity

Full article - 20218

Understand the wavelengths, tissue rich and poor in mitochondria, additional chromophores and dosage ( fluence and power density)

Photobiomodulation focus on Blue and green light

Full article - 2019

Discover more than just the cytochrom C oxydase in mitochondria - More chromophore involved such as Opsine - Light/heat sensitive ion channels

Photobiomodulation on Brain cells

Full article - 2024

Increase Blood FLoa - Decrease oxydative stress - Promote angiogenesis - Inhibit neuronal inflammation - Inhibit apoptosis - Promote neurotrophic secretion - Increase neuron progenitor cells- Increase synaptogenesis

Photobiomodulation action on virus

Received: 21 May 2018

Accepted: 21 June 2018

# Springer-Verlag London Ltd., part of Springer Nature 2018

Laser therapy and epidermal growth factor receptor

The high-level laser therapy was effective in the healing of acneiform rash associated with epidermal growth factor receptor inhibitors with no side effects.

BLUE Laser

Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: clinical and histological findings after excisional biopsy of benign oral lesions

“Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: clinical and histological findings after excisional biopsy of benign oral lesions”

Blue Laser on wound healing

2023 - Full article

Growth factor - Nitriic oxide - Platelet rich plasma - Stem cells

Mechanism and dosage

High power Blue Laser, a versatil tool in Dermatology

Publish 2021

Blue Laser for treatment of solar lentigines

2021 - Full article

Fractional Laser

Laser effects on Skin rejuvenation

2020 - Full article

Mechanism of ablative - non ablative fractional laser - thermal lasers on skin rejuvenation

Nonablative Fractional Laser to decrease risk of keratinocyte carcinoma

2023 - Abstract

Conclusion "NAFL treatment was associated with a decreased risk of subsequent facial KC development and may have a benefit for KC prophylaxis."

Laser Assisted Drug Delivery post fractional lasers

Publish 2019 -

Mechanism of penetration, the microchannels and the inflammatory response - Different dynamic between size molecules and hydro/lipo -phylic molecules

EQUINE

Hypergranulating wounds on horses

This study compares the healing times of hypergranulation wounds on horses with and without debridement before treatment, evaluating four different treatment techniques. The results are quite impressive: laser therapy at 10J/cm² shows the best outcomes, followed by red mercury, copper, silver, and bandage alone.

Tendon & Ligaments

This study evaluates the effects of High-Intensity Laser Therapy (HILT) on tendon and ligament injuries in horses. Twenty-six horses with tendinopathies and desmopathies were randomly assigned to HILT-treated or non-treated groups, with clinical and ultrasound assessments conducted. HILT showed analgesic and anti-oedema effects, reduced lesion percentage, but did not affect lesion echogenicity, supporting its use as a physiotherapeutic technique for tendon and ligament injuries in horses.

Effects of Low-Level Laser Therapy on Back Pain in Horses

This study evaluates low-level laser therapy (LLLT) and chiropractic care for treating back pain in 61 competitive western performance horses. Horses were assigned to laser therapy, chiropractic, or combined treatment groups, with outcome measures including back pain, muscle tone, and stiffness. The results show that LLLT significantly reduced back pain and stiffness, and combining LLLT with chiropractic care produced additional benefits, supporting a multimodal approach for treating back pain in horses.

Practical Rehabilitation and Physical Therapy (Equine)

Physical treatment and rehabilitation are crucial for equine athletes, requiring accurate diagnosis and measurable treatment outcomes. This review covers therapeutic modalities accessible to general veterinarians, including thermal therapy, therapeutic ultrasound, extracorporeal shock wave therapy, and laser treatments. Additionally, it discusses manipulative therapies such as stretching and core strengthening exercises.

Using Short Term of High Power Laser Therapy in Horse's Tendons

High-power laser therapy effectively treats tendon disorders and reduces pain in injured sport horses, as shown in this study involving 50 racing horses aged 5 to 15. Significant improvements in lameness and ultrasound scores were observed following treatment, with a strong correlation between lameness improvement and tendon healing. This suggests that high-power laser therapy is a beneficial and uncomplicated method for addressing tendon damage in horses.



CASE STUDIES

CASE STUDY: Leg Wound Trauma (Equine)

Study by:

Dr Anabelle Trainor Bsc, DVM

Crown Equine Veterinary Services (Melbourne)

CASE STUDY: Non-healing Wound (Equine)

Study by:

Dr Anabelle Trainor Bsc, DVM

Crown Equine Veterinary Services (Melbourne)

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